Enhancing health. Sustaining our planet.

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Inspired by nature. Perfected by science.

For too many diseases, the best available treatment options simply aren’t good enough. Drug discovery has been limited by an inability to seamlessly fuse the power of both chemistry and biology to create a new frontier of therapeutic potential.

At Double Rainbow, we’re harnessing the power of natural evolution through bioengineering to improve the quality of human health and ensure the sustainability of our planet.

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Our Approach

Building on ancient healing wisdom and grounded in modern science.

With nature as our mentor, our approach leverages advances in genomics, metabolomics, and synthetic biology to unlock new levels of richness and efficacy in natural chemistry.

By understanding nature’s sophisticated biochemical systems, we can bring therapeutics to the world at scale without harming the environment.

01 Read Life

Decode the genetic content of plants and other organisms that harbor unique medicinal or biochemical properties.

02 Decipher Biology

Understand nature’s strategies to systematically produce and modify diverse complex bioactive molecules.

03 Bioengineer Chemistry

Use precision bioengineering to create valuable nature-derived compounds and new nature-inspired therapeutics.

04 Enhance Life

Improve human health and well-being by developing diverse novel therapeutics.

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Our Platforms

A new class of sustainable therapeutics born from nature’s blueprint.

Our platforms use synthetic biology instead of organic chemistry to create precision-engineered products that treat human diseases and enhance whole system vitality.

By charting unexplored territories of therapeutic modes, we are uniquely positioned to address areas of significant unmet medical needs like oncology, neurological diseases, and metabolic disorders.

Enzyme Modification Platform

Delivering better medicines through intentional enzymatic modifications

We’re exploring natural sugar biochemistry, or glycosylation, as a novel therapeutic modality. Our proprietary enzyme library delivers improved product profiles for novel, existing, or previously abandoned medical compounds.

How it Works

First, we identify suitable drug candidates for glycosylation, then bioconjugate diverse sugar groups like glucose, xylose, GlcNAc, and more.

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Molecular Biosynthesis Platform

An environmentally friendly approach to well-being

Through efficient and sustainable bioproduction, we recreate valuable natural products with pure essential bioactive ingredients — helping both people and the planet stay healthy.

How it Works

We can isolate the specific gene set needed to sustainably produce valuable natural products and analogs in bioengineered cell factories.

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Redefining what it means to be well.

Restoring life. Restoring health. Restoring harmony.

Our Team

  • A portrait of   Jing Ke Weng

    Jing-Ke Weng is Co-Founder of Double Rainbow. Currently, he is a member of the Whitehead Institute for Biomedical Research, and an Associate Professor of Biology at Massachusetts Institute of Technology.

    Dr. Weng’s work explores plant chemistry and biochemistry to tackle human diseases, including cancer, metabolic syndromes and neurode­gen­er­a­tive conditions. His research focuses on understanding the origin and evolution of plant specialized metabolism at enzyme, pathway, and systems levels, as well as how plants exploit discrete small molecules to interact with their surrounding biotic and abiotic environments. As of May 2021, his work has been featured in over 120 publications, and cited more than 5,000 times.

    He has won numerous awards including the Beckman Young Investigator Award (2016), Alfred P. Sloan Research Fellow (2016), Searle Scholar (2015), Pew Scholar in the Biomedical Sciences (2014), American Society of Plant Biologists Early Career Award (2014), and Tansley Medal for Excellence in Plant Science (2013).

    Dr. Weng received his B.S. (2003) in Biotechnology from Zhejiang University, China, and his Ph.D. (2009) in Biochemistry from Purdue University. He was a pioneer postdoctoral fellow at the Salk Institute for Biological Studies and Howard Hughes Medical Institute between 2009 and 2013. Dr. Weng has served as a scientific advisor for Galixir, Inari Agriculture, BGI and Phylos Bioscience.

  • A portrait of   Tian Xu

    Tian Xu is Co-Founder of Double Rainbow. Since 2018, he is Chair Professor of Genetics and Vice-President at Westlake University. Dr. Xu’s work focuses on mechanisms of growth control and new genetic and biotech methods. His studies have not only elucidated fundamental principles of developmental biology, but also revealed pathogenic mechanisms, and contributed to the development of multiple drugs and to cancer and rare disease diagnosis.

    Dr. Xu is an AAAS Fellow, and the recipient of the Helen Hay Whitney Postdoctoral Fellowship, the Pew Scholar Award, the Tuberous Sclerosis Alliance Rothberg Courage Award, TSC Achievement Award, Distinguished Scientist and SCBA Service Award, Shanghai Science and Technology Award (1st class), and the Magnolia Silver Award.

    He was a postdoctoral fellow at University of California, Berkeley from 1990 to 1993, and an Assistant Professor, Associate Professor (tenured in 2001), and C.N.H. Long Professor of Genetics at Yale University from 1993 to 2018. In addition, he served as Special Advisor to the President of Yale University from 2002 to 2013, and as Vice-Chairman of the Department of Genetics at Yale from 2003 to 2018.

    From 1997 to 2018, Dr. Xu served as an Investigator with the Howard Hughes Medical Institute, as well as an Adjunct Professor and Director of the Institute of Developmental Biology, and Director of the International Collaboration and Research Center for Development and Disease at Fudan University.

    He received his B.S. degree (1982) from Fudan University and Ph.D. degree (1990) from Yale University. Dr. Xu has served as a scientific advisor for CuraGen, Butterfly Network, Hyperfine Research, Quantum-Si, Yiviva, and Fosun Pharma, and is the inventor of more than 20 international patents.

    In addition to Double Rainbow, Dr. Xu is a Co-Founder of LAM Therapeutics (now AI Therapeutics), Drug Farm, and Fosun Lead.

  • A portrait of   Holly Schachner

    Dr. Holly Schachner is Chief Medical Officer of Double Rainbow. A dynamic healthcare leader with extensive experience in medical affairs and late-stage clinical development, Holly is widely recognized as a transformative change agent and highly respected collaborator with business and alliance partners. She has built global medical teams that have launched new therapies and won prestigious awards for their innovation and impact.

    Most recently, Holly was SVP, Therapeutic Head of Clinical Science at MyoKardia, where she led a new therapeutic area focused on diastolic dysfunction, myocardial inflammation, and ischemia. She designed and led a myosin-inhibitor portfolio expansion and partnered with senior leaders to drive the strategy and initiatives to generate clinical data to maximize the medical value of MyoKardia therapeutic solutions.

    Prior to joining MyoKardia, Holly was Chief Medical Officer (CMO) Specialty Medicine at Allergan, where she led the transformation to a matrixed medical organization, and developed innovative and global approaches to education and clinical trials.

    Holly’s career includes leadership roles as North America Medical Head for the Diabetes Cardiovascular (DCV) Business Unit at Sanofi, as well as serving simultaneously as U.S. Medical Chair, meeting with stakeholders on Capitol Hill to gather insights on patient and healthcare system needs. Earlier in her career, Holly held medical leadership positions at Bayer Diabetes Care, Pfizer, Inc., and at Columbia University.

    Holly holds a Doctor of Medicine (MD) degree from the SUNY, Stony Brook and a Bachelor of Arts in Psychology from the University of Michigan. She completed her Pediatric Residency and Pediatric Endocrinology Fellowship at Mount Sinai Medical Center in New York City.

  • A portrait of   Jamie Jones

    With over 25 years of biotech and pharmaceutical experience, Jamie is a dynamic and innovative senior executive with expertise in leading multifunctional teams. He succeeds by challenging them to overcome obstacles and barriers through developing strong, in-depth strategic relationships with corporate partners, community leaders, and key stakeholders, ensuring trustworthy alliances, and leading to optimal business results.

    Before joining Double Rainbow, Jamie held leadership positions in commercial and business development capacities with large, mid, and small-cap companies, including Chief Business Officer of Kalos Therapeutics, where he engineered a $90M Series B capital-raise and co-development and licensing agreements with two oncology life-science companies.

    At Alnylam Pharmaceuticals, Jamie served as Vice-President, U.S. Business Operation, where he led the highly successful launch and commercial operations of ONPATTRO®, ranked among the best rare drug launches in the previous 15 years. Prior leadership roles include positions at Gilead Sciences, Novo Nordisk, Eli Lilly & Co., and Pfizer Inc.

    Jamie is currently a Board Advisor to Kalos Therapeutics. He has a B.S. in Finance and M.B.A. from the University of Central Florida.

  • A portrait of   Cavan Farley

    Cavan Farley is Vice-President, Global Business Groups at Double Rainbow. A nationally recognized, award-winning senior executive, Cavan has 20 years of leadership experience at global, research-based pharmaceutical companies. She has held critical roles across varied business channels, including market access, sales and marketing, and planning and execution.

    Considered an inspired leader and team motivator, Cavan employs a multi-dimensional approach to competitive market opportunities to drive differential performance and ensure successful launch. Experienced at solving complex business challenges, she is skilled at people development and cross-functional collaboration; attributes honed in commercial leadership positions at Gilead Sciences and GlaxoSmithKline.

    Prior to joining Double Rainbow, Cavan held the position of Executive Director Corporate Accounts, Market Access for Allergan (now AbbVie). In this role, she led a team responsible for a broad set of market access customers including national and regional payers, the Specialty Pharmacy and Federal Channels, as well as Kaiser, totaling more than $1B in U.S. sales.

    She successfully designed and implemented an innovative account strategy and structure in 2019 for, optimizing access and portfolio performance of approximately $250M, and leading her team to double-digit net sales growth year-over-year, subsequently out-pacing the nation for the previous three years. In addition, she successfully executed launch access strategies for UBREVLY, VRAYLAR, XEN and DURYSTA, including pre-approval engagement and post-approval reviews, negotiation and coverage.

    Cavan’s career has informed her knowledge expertise across varied disease states and therapeutic areas, including infectious and rare diseases, neurology and immunology amongst others.

    She has a B.A in Journalism and Business from the University of Richmond.

  • A portrait of   Kevin O Driscoll

    With over 20 years in the biophar­ma­ceu­tical industry, Kevin is considered an agile and accomplished leader. He has held diverse roles across the research, business, and operational channels, offering comprehensive scientific and commercial experience to Double Rainbow. His proven track record in business development, corporate strategy, new product planning and private and public fundraising, is key to Double Rainbow’s growth strategy.

    Prior to joining Double Rainbow, Kevin was the Senior Director of Business Development and Licensing at Pulmatrix where throughout a 12-year tenure, he played an integral role in taking the company public. His leadership responsibilities included corporate strategy, valuation, accretion/​dilution modeling, commercial and market assessment evaluations, in-licensing and out-licensing, and research collaborations.

    Prior to joining Pulmatrix, Kevin was a Scientist at Alkermes and was responsible for early preclinical testing of the company’s lead development programs for pharmaceuticals and pharmacodynamic evaluations of proprietary pulmonary drug delivery technology. He began his career as a Researcher at The Harvard School of Public Health.

    Kevin holds a Bachelor of Science degree in biology from Saint Michael’s College, and an MBA, Global Management from Babson F.W. Olin Graduate School of Business.

  • A portrait of   Phil Kasprzyk

    His very accomplished 25-year career encompasses leadership and advisory positions in both scientific and commercial operations in startup biotech and medium-sized pharma companies.

    Philip began his career as a Senior Staff Scientist in Molecular Oncology, before holding several Director of Oncology positions, (Pharmacology), at Ipsen where he was also the research representative on the Governance Board for the Ipsen Life Sciences Program at the Salk Institute.

    Due to his distinguished scientific career in oncology, Philip’s advisory positions include a role as Scientific Advisor, Sales and Marketing Assistance at OncoVet Clinical Research, (OCR) in Lille, France, where he advised on the technical and scientific accuracy of published documents, as well as assisted in the design of animal studies. His expertise was also sought by the Montréal based Oncodesign, where he managed Business Development and Pharmacology Operations for North America, and for the US-based Fenney Law Group, where Philip served as advisor for scientific patents, relative to biology and oncology. His commercial experience also includes partner and asset evaluation, alliance management, in-licensing and out-licensing, and therapeutic area company direction.

    Inspired by collaboration, Philip has been consistently recognized by leadership for promoting cross-functional partnership, a hallmark of the Double Rainbow culture. He enjoys working with enthusiastic teams and spearheading effective collaborations to accelerate the drug development process.

    Philip received his B.S. from Utica College of Syracuse University, and his Ph.D. from the Pennsylvania State University, followed by postdoctoral fellowships at the National Institutes of Health (NIH), first in the National Heart, Lung and Blood Institute, (NHLBI Branch) and then at the National Cancer Institute, (NCI).

  • A portrait of   Sheng Ding

    Sheng Ding is the Head of Enzyme Modification Platform for Double Rainbow. Currently, he is leading the development of our cutting-edge drug discovery pipeline. Dr. Ding’s work explores the intersection of plant chemistry and biochemistry to tackle human diseases, including cancer, metabolic syndromes, and neurodegenerative conditions.

    Before joining Double Rainbow, Dr. Ding was a Research Specialist with the Yale School of Medicine, where his research focused on developing novel mouse models for human diseases by transposon-mediated mutagenesis and systematic phenotyping. Dr. Ding completed his Ph.D. at Fudan University in China, where he received the Chinese National Excellent Doctoral Dissertation Award in 2009 for his work focused on study mammalian development and human disease using genetically modified mouse models.

  • A portrait of   Chris Vickery

    Christopher Vickery is the Head of Molecular Biosynthesis Platform for Double Rainbow. Currently, he is leading the development of our novel bioceutical pipeline. Dr. Vickery’s work explores the intricacies of plant chemistry to sustainably recreate valuable natural products with pure essential bioactive ingredients.

    Before joining Double Rainbow, Dr. Vickery was a Postdoctoral Research Fellow with Harvard Medical School, where his research focused on microbiological techniques and the manipulation of membrane proteins. Dr. Vickery completed his Ph.D. at the University of California, San Diego and the Salk Institute for Biological Studies, where his work focused on post-translational modification of natural product biosynthetic enzymes in bacteria and plants.

  • A portrait of   Mingli GNS01181 C

    Mingli Ye is the Head of Operations for Double Rainbow. With experience across industry and leading academic institutions, she brings a rich history of effective program management to the Double Rainbow leadership team.

    Before joining Double Rainbow, Dr. Ye was most recently a Research Scientist in the Jack H. Skirball Center for Chemical Biology and Proteomics at the Salk Institute for Biological Studies. In addition to her professional experience, Dr. Ye has been awarded the Center for Pharmaceutical Processing Research (CPPR) Award for Freeze-Drying of Pharmaceuticals and Biologicals, the Charles V. And Madonna Dienhart Flemming Pharmacy Award, as well as the Purdue University Graduate School Excellence in Teaching Award. Dr. Ye completed her Ph.D. in Pharmaceutical Science at Purdue University and her Masters of Engineering in Chemical Engineering at the Beijing University of Chemical Technology.

  • A portrait of   Grant Smith

    With experience across the biotech and pharmaceutical industry, Grant is an accomplished public affairs professional with a demonstrated history of delivering impactful communications strategies. He succeeds by developing trustworthy relationships with external partners and stakeholders to help tell corporate stories, translating to optimal business results.

    Prior to joining Double Rainbow, Grant held public relations and communications positions within two of the world’s largest biophar­ma­ceu­tical companies, developing and executing communications strategies across R&D, product and corporate initiatives. His expertise includes leading the development of integrated analytics methodologies, which produce data-driven, cross functional campaign strategies that maximize external impact and optimize resource allocation.

    At Eli Lilly and Company, Grant served as Manager, Global Business Communications, where he led product communications across eight metabolic products, including trial readout communications related to the landmark cardiovascular studies of blockbuster SGLT2 inhibitor JARDIANCE®.

    As Associate Director, Science Communications for AstraZeneca, Grant delivered executive communications strategies for the Executive Vice President of Global Oncology R&D, positioning the newly formed organization as a strategic leader in scientific innovation.

    Prior roles include leading partnership and early science communications for MedImmune and supporting digital government affairs communications for Eli Lilly and Company.

    Grant has a B.S. in Public Affairs Management and an M.P.A. from Indiana University’s O’Neill School of Public and Environmental Affairs.

Join us in leading the future of sustainable medicine.

Our values are what ground us, keep us connected, and help us balance human health with long-term sustainability.

01 Diversity

We believe a diverse system is an innovating system, a thriving system. We delight in cross-disciplinary partnerships that advance our thinking, our science, our reach.

02 Harmony

We believe homeostasis is the optimal state. We take pride in balancing the ancient and the modern, the natural and the lab-made.

03 Wonder

We believe awe is a scientific responsibility. We embrace complexity. We uphold the wisdom of the wild and the intricacies of engineering.

04 Precision

We believe in the power of systems, structures, and specificity. The earth has its rules, and we honor them along with our own scientific and technological expertise.

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